https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Genetic effects on the timing of parturition and links to fetal birth weight https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52463 Wed 11 Oct 2023 15:07:44 AEDT ]]> Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53968 Tue 23 Jan 2024 15:33:56 AEDT ]]> Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45201 P = 3.96 x 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.]]> Thu 27 Oct 2022 15:06:39 AEDT ]]>